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Elevated NNMT activitycommon in obesity and metabolic syndromedepletes NAD+ reserves by shunting nicotinamide into an excretory pathway rather than salvaging it for NAD+ biosynthesis

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This triggers the release of harmful cytokines like IL-8 and MCP-1, which stiffen arteries, raise blood pressure, and ultimately damage your kidneys

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This is supported by other studies in healthy volunteers, consuming alcohol before an oral glucose test (Svartberg et al., 1998), after an overnight fast (Calissendorff et al., 2012) or after consumption of red wine (Abraham et al., 2016)