Elevated cortisol promotes visceral fat storage, breaks down muscle tissue, increases appetite, and impairs insulin sensitivity
This means that while overall weight decreases substantially with Semaglutide, the ratio of visceral to subcutaneous fat may not change as much as users hope
The FDA prescribing information for both Mounjaro and Zepbound and clinical trial data consistently demonstrate that tirzepatide is associated with modest decreases in both systolic and diastolic blood pressure rather than increases
People with a personal or family history of MEN 2 are among those who shouldnt take semaglutide
doi: 10.1016/j.jacc.2023.08.003 [92] Akazawa N, et al
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