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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations GSH: reduced glutathione GSSG: glutathione disulfide GS: thyil radical ROS: reactive oxygen species RNS: reactive nitrogen species RS: reactive species -GCS: -glutamylcysteine synthetase GPX: glutathione peroxidase GR: glutathione reductase GST: glutathione S -transferase GSNO: nitrosoglutathione G6PD: glucose-6-phosphate dehydrogenase NAC: N -acetyl-L-cysteine NO: nitric oxide protein-SSG: protein glutathionylation protein-SNO: protein nitrosylation References Galluzzi L, Maiuri MC, Vitale I, Zischka H, Castedo M, Zitvogel L et al

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Only higher intravenously administered doses up to 51.3 mg/Kg (around 3,591 mg per individual) were associated with renal toxicity (111)

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3 , e324 (2005)

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Introduction Vitiligo is an autoimmune disease characterized by progressive skin depigmentation and the appearance of white patches throughout the body, caused by significant apoptosis of epidermal melanocytes ( There is no known cure for vitiligo, but there are several management strategies to reduce the spread of white skin patches and to attempt to re-pigmentate the affected areas

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