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Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

HGF/c-Met signaling is a well-established oncogenic pathway: c-Met is amplified or overexpressed in multiple cancers (gastric, lung, renal, hepatocellular) HGF/c-Met activation promotes tumor cell proliferation, survival, invasion, and metastasis c-Met inhibitors are FDA-approved cancer drugs (cabozantinib, crizotinib, capmatinib) A compound that potentiates HGF/c-Met signaling raises theoretical concerns about promoting tumor growth or transformation with chronic use

In the spinal cord, GPX4 is primarily expressed in neurons and oligodendrocytes, but not in astrocytes ( in vivo ( The Effect of Ferroptosis on TBI Spinal cord injury and TBI have similar pathophysiological mechanisms, and ferroptosis occurs in TBI

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The Roche European American Cataract Trial (REACT): A randomized clinical trial to investigate the efficacy of an oral antioxidant micronutrient mixture to slow progression of age-related cataract