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The relationship between GLP-1 receptor agonists and inflammation remains an active area of clinical investigation, with ongoing studies exploring mechanisms and clinical applications beyond traditional metabolic indications
Mechanisms include increased aromatisation of testosterone to oestradiol, functional hypogonadotropic hypogonadism, inflammation, oxidative stress and impaired testicular thermoregulation
The medication is designed with built-in flexibility
In the ten phase 3a trials comprising the programme, relevant contemporary T2D treatment options were used as comparators in head-to-head comparisons
Additionally, a large-scale observational study involving over 40,000 Chinese OA patients with comorbid T2DM reported that GLP-1RA therapies offered disease-modifying benefits [49]
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