Studies indicate that p53 binds the SLC7A11 promoter, suppressing its expression and limiting GSH production, thereby promoting ferroptosis (83,84)
Nature Reviews Gastroenterology & Hepatology, 23 (1), 6-28
Thus, by using de novo biosynthesis of Cys via the methionine (Met) cycle and transsulfuration pathway to generate intracellular Cys, cells can extract the reduced S from Met (Fig
Katerji M, Barada K, Jomaa M, Kobeissy F, Makkawi A-K, Abou-Kheir W, Usta J
In the in vitro infection assay (Fig
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