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The practice of doubling the infusion rate is increasingly accepted, but tripling or quadrupling the dose remains more controversial

Individuals with higher oxidative stress levels, significant sun exposure history, or hormonal pigmentation may require longer treatment durations

meningitidis rapidly colonized capillaries and arterioles before the activation of an efficient inflammatory response

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These therapies display higher efficiency compared to classical senolytic drugs (BCL-2 or tyrosine kinase inhibitors) but for some of them, such as NA + /K + ATPase inhibitors, clinical development could be complex in the light of strong cardiotoxicity associated with this class of molecules

10.1074/jbc.R111.283432 J