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In doxorubicin-induced cardiotoxicity, PSG-1 confers cardioprotection by selectively suppressing the mitochondrial intrinsic apoptotic pathwayevidenced by enhanced MnSOD activity, preservation of mitochondrial membrane potential, inhibition of mitochondrial permeability transition pore (mPTP) opening, and attenuated cytochrome c release into the cytosol (Ubaidillah et al., 2016)
Nader E, Romana M, Guillot N, Fort R, Stauffer E, Lemonne N, et al
How long does it take for niacinamide and vitamin C to fade dark spots
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Aging Cell 23 (2), 14041
doi: 10.1016/j.ghir.2004.12.002 136 SymondsRP
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