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Therefore, further research into the pharmacodynamics, safety, and efficacy of dual inhibitors in combination with immune checkpoint inhibitors (ICIs) is of prime importance and warrants further investigation

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MACS2 software (v2.2.7.1) was used for peak calling

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7Dipeptidyl peptidase-4 (DPP-4) inhibitors DPP-4 inhibitors act primarily by blocking the enzyme DPP-4, which is an aminopeptidase that is widely expressed in many tissues, such as the liver, lungs, kidneys, intestinal brush border membranes, lymphocytes, and endothelial cells [55]

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Direct regulation of cancer cell proliferation, apoptosis, migration and invasion GLP-1RAs exert their biological effects primarily by binding specifically to and activating the GLP-1 receptor (GLP-1R) [17, 38, 55]

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