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NICE TA875 confirms that gastrointestinal (gut) side effects are expected with semaglutide and recommends a gradual dose escalation to minimise discomfort

There is much debate surrounding the tolerability of an increased risk of DKA, with comparisons being made with troglitazone and its subsequent removal from the market where the risk of fatal liver failure was greater than the current risk of DKA with SGLT2i use [31]

Mounjaro led to more weight loss than Wegovy (semaglutide alone) in SURMOUNT-5 and CagriSema (semaglutide plus amylin) in REDEFINE 4

So the key question is not just what the picture shows

Ondansetron (Zofran) 4 mg orally dissolving tablets, taken 30 minutes before meals, can block serotonin-mediated emesis

Antibodies were detected under a Leica DM6000B fluorescence microscope using Leica LAS X software