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Alcoholism, malabsorption, prolonged stress, tapeworm infestation, vegan diets, celiac, hyperthyroidism, hepatic-biliary tract disease, persistent diarrhea, ileal resection, pancreatic cancer, renal disease, macrobiotic diets or other restrictive diets

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and (iv) loss of function mutations in PTEN , encoding the phosphatase PTEN which inhibits PI3K

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promoted cardiomyocyte survival (PMID: 25015963) Wound Healing: Accelerated wound closure, reduced scarring in dermal wound models (PMID: 25015963, PMID: 27450738) Corneal: Enhanced corneal epithelial healing