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Pathogenic genetic variants in NAD-synthesis enzymes lead to NAD + deficiency 14

The second co-primary endpoint of change from baseline quality of life favored tirzepatide

Titration: Increase by ~200 mcg every 2 weeks: 400 mcg (Weeks 34), 600 mcg (Weeks 56), 800 mcg (Weeks 78)

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After stopping tirzepatide, increased blood glucose monitoring is recommended for at least 2-4 weeks