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Research Sources: New England Journal of Medicine: Tirzepatide Once Weekly for the Treatment of Obesity. Available here American Diabetes Association: The Effect of Tirzepatide during Weight Loss on Metabolic Adaption, Fat Oxidation, and Food Intake in People with Obesity. June 20, 2023
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Specifically, high attained dose was associated with lower: all-cause mortality (RR = 0.42, P 25% group, with a mean patient-level change of 0.2% versus 0.8% relative to the pre-treatment baseline measurement ( P 25% weight loss group (126 mmHg versus 13 mmHg, P 25% weight loss group (75.4 mmHg versus 78.0 mmHg) and progressively larger patient-level declines relative to baseline across the different weight loss strata ( P = 0.002
Some prescribers are now combining it with tirzepatide for PCOS patients who also struggle with weight management
