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The most common adverse effects from the SURMOUNT trials include: Nausea: 24-33% of participants (dose-dependent) Diarrhea: 18-25% of participants Constipation: 13-17% of participants Vomiting: 8-12% of participants Decreased appetite: 10-15% of participants Most of these effects are mild to moderate and occur primarily during dose escalation periods

doi: 10.1161/CIRCULATIONAHA.121.055459 22 OvergaardRVHertzCLIngwersenSHNavarriaADruckerDJ

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Additionally, since these drugs decrease the rate of stomach emptying, it is important to stop these medications before surgery, or else food can remain in the stomach for too long, leading to complications