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[4] Microdosing offers a psychological and physiological safety net

Beyond their role in glucose metabolism, GLP-1 and its receptor agonists have emerged as multifunctional agents with broad cardiometabolic, renal, and immunomodulatory benefits

This was corroborated by a marked effect on cAMP signaling in -arrestin-less HEK293 cells, which progressively diverged with longer exendin-4 treatment, reminiscent of the effect of exendin-phe1 on beta cell cAMP production

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The study population was mostly older, white, and male