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[125] The ability to absorb vitamin B 12 declines with age, particularly in individuals over 60
Unlike stimulants that artificially boost energy through sympathetic nervous system activation, the energy improvements from NNMT inhibition come from enhanced cellular metabolism
The most notable evidence proving this comes from a 68-week clinical trial involving 1961 patients and a once-a-week dose of 2.4 mg: The mean change in body weight from baseline to week 68 was 14.9% in the semaglutide group as compared with 2.4% with placebo, for an estimated treatment difference of 12.4 percentage points (95% confidence interval [CI], 13.4 to 11.5
Adults over 60 are more likely to have low levels of vitamin B12
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