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However, concerns regarding the safety of such agents, in particular the increased risk of diabetic ketoacidosis (DKA) with SGLT2is, have restricted their widespread adoption in type 1 diabetes [15]

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10.1161/CIR.0000000000001123 2

For athletes and active adults, that matters for reasons that go far beyond aesthetics

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Accompanied by neurologic symptoms such as leg weakness, numbness, bowel or bladder dysfunction, or saddle anesthesiathese are red flags for cauda equina syndrome or severe nerve compression requiring emergency evaluation