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Common Side Effects and Mitigation Strategies Nausea is one of the most frequent side effects reported

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The bonus is that semaglutide lasts longer in your body than natural GLP-1, so you only need a weekly injection

Watch for dizziness on standing, fatigue, dry mouth despite drinking fluid, and dark urine

Cleveland Clinic: Massachusetts General Hospital: Preserving Lean Body Mass in Patients Taking GLP-1 for Weight Loss Mayo Clinic: Strength Training: Get Stronger, Leaner, Healthier U.S