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When directly injected, IGF-1 rapidly diffuses away from the injury site, making it difficult to maintain therapeutically effective concentrations ( Secondly, despite its promising results in vitro and in animal models, clinical trials have not consistently shown a significant role for IGF-1 in promoting tendon repair ( in vivo environment in humans is difficult to replicate in laboratory settings

Another talks about recovery, inflammation, skin, connective tissue, and barrier models all at once