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Cell Sci., 108(l):73-83, 1995

Describing herself as largely 'the lab rat' when she joined the diabetes team, Knudsen remembers she spent 'the first year in a cold room with three technicians to screen hundreds of thousands of compounds to see if they could wedge into the GLP-1 receptor and other targets of interest just snugly enough to stimulate insulin secretion.' To help speed up the screening process, Knudsen devised a method to test 96 candidates in one go instead of just one

BMI remained higher in the GLP-1 group even after matching, so some residual differences between the groups stayed in

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present a mouse model of a specific BBS subtype with genetic deletion of the Bbs5 gene

This analysis concludes that while GLP-1 agonists demonstrate significant promise, their ultimate impact depends on addressing cost, accessibility, and long-term sustainability concerns