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In some embodiments, the otic formulation comprises between about 0.0001% to about 20% by weight of the weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

In particular, dystrophin-associated protein complex links AQP4 aquaporin channels and K ir 4.1 channels in the endfeet: one of the key components of astrocytic homoeostatic hardware

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Each compound included in this set is widely referenced in peer-reviewed scientific literature for its role in various cellular signaling pathways, structural organization mechanisms, and peptide-mediated biological interactions