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Quick Answer: The largest Phase IIb trial (536 subjects, 24 weeks) did not hit statistical significance for weight loss ending commercial development in 2007

Research findings on glucose homeostasis [6] : Oral glucose tolerance testing showed no negative impact on glucose levels in human subjects No insulin sensitivity changes following chronic exposure Fat-reducing effects occur without inducing insulin resistance Avoids common metabolic complications associated with hGH therapy This metabolic selectivity positions the peptide as targeting adipose tissue lipid metabolism without broader endocrine disruption affecting growth, glucose regulation, or protein synthesis

Together they could create a complete metabolic combination , thermogenesis + lipolysis + appetite suppression

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