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Month 1: 0.25 mg weekly (starting dose) Month 2: 0.5 mg weekly Month 3: 1.0 mg weekly Months 45: 1.7 mg weekly Maintenance: up to 2.4 mg weekly Not everyone needs the highest dose

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The role of glucagon in maintaining glucose homeostasis by increasing hepatic gluconeogenesis and glycogenolysis in response to low glucose levels has been exhaustively studied

Estrogens exert neuroprotective effects by modulating synaptic plasticity, enhancing mitochondrial bioenergetics, and reducing oxidative stress and inflammation

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Finally, this review highlights the value of combined approaches which have been shown to improve clinical efficacy