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The trial included reversion to normoglycaemia as its primary endpoint and demonstrated that semaglutide significantly increased the rate of glycaemic normalisation compared with placebo, alongside substantial reductions in BW

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That difference in signal duration explains almost every divergence in the side-effect profiles

Once you reach your maintenance dosetypically 0.5 mg, 1.0 mg, or 2.4 mg per week, depending on your weight loss response and medical needsearly timing becomes far less critical