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Best Pract Res Clin Gastroenterol 29(3):503521
The diagnosis is based on the finding of cysteinylglycinuria and decreased activity of dipeptidase, and is established by: Increased urinary excretion of cysteinyl glycine Normal concentration of cysteinyl glycine in plasma Low activity of dipeptidase in cultured skin fibroblasts and/or red blood cells
10.1016/S0140-6736(08)61246-5 44 GaultV
In the literature mainly the receptor-mediated pathways were investigated to increase the BBB penetration of dopamine nanoformulations
Therefore, Design for Manufacturing (DfM) must be introduced from the initial design stage
Shaded diamonds represent intracellular drug and drug metabolites
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