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Microsomal GST1 (MGST1) and GSTP1-1, which are frequently overexpressed in cancer cells, contribute to DOX resistance

Mistake 1: Using acetate protocols for arginate dosing The improved bioavailability of the arginate form means that dose-for-dose, it delivers more active peptide to target tissues than the acetate form, especially via oral routes

58 Interestingly, the expression of this enzyme does not fulfill an instantaneous snapshot of the blood toxicity, but an average value over a time span of about 2/3 months (corresponding to the mean life of the erythrocyte) as it is exclusively expressed during erythropoiesis

(2019) 8:e13