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Both mistakes distort the science

False-positive selections and contaminants were excluded through iterative rounds of heterogeneous classification using three references and four decoy classes generated from noise particles through ab initio reconstruction in cryoSPARC (v4.5.0), resulting in stacks of 877,231, 815,775, and 906,048 particles from each dataset

doi: 10.2337/dbi21-0004

Wolfram, S., Wang, Y