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Oral versus intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency: a pragmatic, randomised, multicentre, non-inferiority clinical trial

Most researchers find standard protocols sufficient

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The most common side effects are extremely mild and infrequent, primarily involving occasional skin irritation, mild redness, or transient tingling sensation in a small percentage of users, typically resolving without intervention and not requiring discontinuation