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These nanoparticles simultaneously inhibit ferroptosis by chelating iron ions, scavenging free radicals, and inhibiting PDE4 enzyme to activate the cAMP/PKA pathway, thereby enhancing the survival rate of retinal ganglion cells (182)

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PloS Pathog (2023) 19(1):e1011108

Potential benefit - A patient whose biomarkers suggest rapid metabolism of GLP-1 drugs might be offered a longer-acting formulation, while someone with strong GIP responsiveness could start on a dual-agonist right away, avoiding months of trial-and-error

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How nucleotide excision repair protects against cancer