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Oxidation: Copper ions can catalyze oxidation reactions

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Blocks NNMT in fat cells In 3T3-L1 mouse fat cells, 30 M of 5-Amino-1MQ for 24 hours strongly lowered 1-MNA levels direct proof of NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)

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In addition, compared with known lipid-lowering drugs, natural drugs have the advantage of multiple targets and multiple pathways in the treatment of DKD, but their mechanism of action and scope of application have not yet been clarified