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Cassia alata ethanolic leaf extract (CALE) reduced autophagic necrotic apoptosis in diabetic nephropathy by inhibiting the expression of proteins such as LC 3-IL,IL-11,RIP-IL 1 ,p38 MAPK through in vitro and in vivo experiments, which opens up new avenues of research to study the efficacy of CALE in diabetes-related complications ( In summary, Chinese medicine (Chinese herbal formulas, Chinese patent medicine, compounds and extracts from Chinese herbs) may play a role in the treatment of DN by inhibiting the production of ROS, alleviating oxidative stress and inflammatory responses, restoring mitochondrial function, and decreasing apoptosis, thereby reducing proteinuria, improving renal function, and decreasing renal pathological damage

Historia y desarrollo Epitalon fue desarrollado en el Instituto de Bioregulacin y Gerontologa de San Petersburgo por Vladimir Khavinson y colaboradores