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The most straightforward approach involves the use of small interfering RNAs (siRNAs) or antisense oligonucleotides (ASOs) to reduce KRAS expression through mRNA degradation

Mod Pathol 1999

Further studying of the mechanism shows that, in a rat model of doxorubicin-induced nephropathy, HKC can downregulate the protein expression of transforming growth factor (TGF)-1 and the p38mitogen-activated protein kinase (MAPK) by suppressing the p38/ MAPK signaling pathway [37,38]

This test wont return in time to affect clinical management

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"Rarely, serious side effects can happen