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Varga, et al., Neurochem

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Ferrannini E, Solini A

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Sirtuin Activation: It is the obligatory substrate for Sirtuins (SIRT1-7), the "longevity genes." High-dose NAD+ activates SIRT1, leading to the deacetylation of FOXO3a (stress resistance) and PGC-1alpha (mitochondrial biogenesis)

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