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Nature (2019) 575(7784):68892

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Hierarchical clustering of commonly engaged proteins by the fold increase in target engagement in senescent versus non-senescent conditions (referred to as senescence selectivity) identified broadly highly-reactive proteins, clusters of proteins with specificity to certain chemotypes and others (such as GPX4) that were enriched in probes related to three different SCLAs (Fig

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doi: 10.1002/bdr2.1769

Nevertheless, the specific processes by which hyperhomocysteinemia triggers ROS generation and the specific ROS origins remain unidentified