Treatment stage What may be common What deserves attention Week 1 Nausea, fullness, reduced appetite, bloating, indigestion, diarrhea, constipation, fatigue Repeated vomiting, severe pain, inability to stay hydrated Weeks 2 to 4 Early symptoms may settle, persist, or fluctuate Symptoms interfering with eating, drinking, or daily function Weeks 5 to 8 Symptoms may reappear after clinician-directed dose escalation A significant return or worsening of gastrointestinal symptoms Months 2 to 3 Some patients tolerate treatment more comfortably
GLP-1 Diet Plan: What to Eat on Ozempic, Wegovy or Mounjaro Updated April 20, 2026, Medical Review by Kaitlyn Wong, RDN If you are on a GLP-1 medication like Ozempic, Wegovy, Zepbound, or Mounjaro, your appetite and digestion can change fast
A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use
Baseline function assessment: Honestly evaluate your current erectile function using the IIEF-5 questionnaire (International Index of Erectile Function)
These metabolic effects of tirzepatide on the liver are currently further investigated in another study (phase II trial) assessing the efficacy and safety of tirzepatide in patients with nonalcoholic steatohepatitis (SYNERGY-NASH, clinical trial registration number NCT04166773) (54, 80)
Jensterle M, Rizzo M, Haluzk M, Jane A (2022) Efficacy of GLP-1 RA approved for weight management in patients with or without diabetes: a narrative review
