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The primary endpoint was often MACE , which typically includes: CardiovasNonfatalath Nonfatal myocardial infarction Nonfatal stroke Some trials also evaluated: Hospitalization for heart failure All-cause mortality Kidney outcomes Progression of albuminuria Decline in estimated glomerular filtration rate, or eGFR Need for dialysis or renal replacement therapy Initially, the goal was to demonstrate non-inferiority , meaning that the drug was not worse than placebo with respect to cardiovascular outcomes