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For semaglutide, the prescribing information says steady-state exposure is reached after four to five weeks of once-weekly dosing
the fullness signal simply arrives much faster than it did before treatment
These effects were subsequently managed through slower absorption kinetics, extended dosing intervals, and careful titration, allowing therapeutic benefit to outweigh adverse events ( 5.1 Peptide YY and the misinterpretation of early tolerability signals Peptide YY (PYY) is secreted postprandially by enteroendocrine L cells and functions as a satiety hormone by activating Y2 receptors in the hypothalamus and brainstem, where it inhibits neuropeptide Ymediated orexigenic signaling ( However, subsequent clinical trials reported high rates of nausea and vomiting, leading to the perception that PYY-based therapies were intrinsically intolerable