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In contrast, the longer-acting GLP-1RAs such as liraglutide and semaglutide, engineered for greater resistance to degradation, demonstrate poor penetration into the central nervous system (Salameh et al., 2020)

Take a look below at our recent articles, which can serve as resources: Thrive Through Change A GLP-1 Menopause Guide

Supplements are most often beneficial as part of a broader approach that includes attention to diet, physical activity, sleep, and stress management

In 2025, the FDA placed several peptides into a limited category, stating they should not be used in compounded drugs due to potential risks

Take home message You can safely take Wegovy alongside sertraline

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