For type 2 diabetes, NICE guidance (NG28) recommends their use as second- or third-line therapy when metformin alone provides inadequate control, particularly in patients who would benefit from weight loss or where hypoglycaemia risk must be minimised
Soluble fibers like psyllium, glucomannan, and inulin create a gel-like matrix in the gut that slows nutrient absorption and triggers incretin hormone secretion, including GLP-1
Around Week 4: Sleep and Energy The first changes patients reliably report are improvements in sleep quality and overall energy
We've seen it work, and we've seen it fail
Mineralocorticoids, whether in excess (Hyperaldosteronism) or in deficiency (Hypoaldosteronism), are linked to oxidative stress, mainly via activation of the renin-angiotensin-aldosterone system (RAAS) and disruption of cellular homeostasis due to sodium and potassium imbalances
If you look at the Biggest Loser studies, you see excessive dieting and exercise that initially produces weight loss but what does extreme calorie restriction ultimately do