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It is characterized by a gamma-peptide bond between the carboxyl group of the glutamate side chain and cysteine (Figure 1)

and ii) direct effects on GPX4, including oxidative damage to its structure, genetic alterations affecting its expression and functionality and the use of specific pharmacological inhibitors (148150)

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Thus, the helical cultivable H

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For instance, angiotensin-converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) drugs are used as an effective first-line therapy