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The contributions of GIP and glucagon receptor activation to bowel changes are not yet well characterised for retatrutide specifically, and any claims about their effects on gut motility or intestinal secretion remain uncertain given the medicine's investigational status

B., Heckenbach, I., Andreasson, L

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Additional research is exploring their influence on immune modulation, oxidative stress response, and inflammatory signaling within the gastrointestinal tract