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New England Journal of Medicine 2017

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Researchers study Orforglipron to evaluate GLP-1 receptor activation, receptor signaling behavior, small-molecule agonist design, and oral GLP-1 pathway models under controlled laboratory conditions

doi: 10.1210/endo.133.1.8319572 47 DamholtABBuchanAMKofodH

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Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardio-renal risk