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In contrast, GLP-1 RAs such as liraglutide and semaglutide represent a substantial pharmacological advance

Recent studies have revealed that SFN regulates fat metabolism both in vivo and in vitro through various mechanisms, including alleviating endoplasmic reticulum stress, inhibiting inflammatory response and improving mitochondrial dysfunction, involving Nrf2/ARE, NF-B, NLRP3 inflammasome, HDAC8-PGC1 axis and other signaling pathways

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Additionally, the evidence base for efficacy and safety specifically in BED populations remains limited

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Any combination use should be guided by available research data