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Kitzman DW, Brubaker P, Morgan T et al (2016) Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: a randomized clinical trial

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Mild digestive discomfort may occur with excessive intake

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However, any FDA-approved medication has different dosing guidelines for different needs (like taking it for diabetes versus weight loss)