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Thus, in studies comparing the expression of recombinant forms of GPx-1 in breast cancer cells, the Leu allele was found to be less responsive to increased selenium levels than the Pro allele (175)

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Human MTHFR consists of an N-terminal catalytic domain (amino acids 1356) which binds 5,10-methylenetetrahydrofolate (5,10-methylene THF), and a C-terminal regulatory domain (amino acids 363656) which binds S-adenosylmethionine (AdoMet, SAM) 16,17

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