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There are 3 pathways related to aging: AMP-activated protein kinase (AMPK) metformin targets this pathway Sirtuin pathways NMN and resveratrol help with this one mTOR this is a pathway in the body activated by protein/amino acids The only way to effect this pathway without fasting or eating a lower protein diet, is through a drug called rapamycin Peter Attia talks about rapamycin extensively in these Podcast Notes he takes a low dose every 4-7 days David doesnt take it he says its too risky to do just yet Source Podcasts The Joe Rogan Experience David Sinclair, Ph.D