Moreover, FosB expression was increased in anorexigenic proopiomelanocortin neurons within the hypothalamic arcuate nucleus, which reduce feeding and have been implicated in promoting sympathetic excitation
This cardiac stress is one of the main reasons the drug is still in testing
That is why U100 syringes with IU markings should be used
A 2024 Medscape report described a patient who relapsed into disordered eating after ten years of recovery, experiencing rapid, dangerous weight loss and a full return of restricting behaviors after starting a GLP-1 medication, ultimately requiring hospitalization
The companion rationale is plausible, not proven
Some research suggests that the glucagon component may have muscle-sparing properties compared to pure GLP-1 agonists, but this requires further study