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The Asp9 forms a hydrogen bond with Arg370, while Ser8 and Ser11 of Tirzepatide form a network of hydrogen bonds involving the receptor residue Glu288, Arg 289, and Asn290

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GLP-1 analogs, like exendin-4, have been demonstrated in rodent studies to decrease nicotine self-administration and to lessen withdrawal symptoms like agitation and anxiety