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Across randomized and controlled studies, GLP-1 receptor agonists reduce fat mass more than lean body mass, functional measures appear preserved, and GLP-1-induced weight loss is largely fat mass with modest absolute lean body mass decline and no consistent deterioration in strength or function

Peter Attia 18 Feb 23 Lean mass loss on GLP-1 receptor agonists: a downside of the miracle drugs Clinical trials have generated impressive data on the effects of GLP-1 agonists on body weight and BMI, but how do these drugs perform in terms of body composition