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After initial rapid progress, the body adapts to new energy balance

169 SIRT1 activates antioxidant transcription factors such as FOXO3a and Nrf2 via deacetylation, 170 upregulating enzymes including superoxide dismutase (SOD) 1/2, GSH-Px, 171 and HO-1

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Discussion The present study elucidates a cohesive mechanism through which the natural alkaloid palmatine alleviates MASLD